γ-secretase相关论文
结构生物学作为现代生命科学的前沿和带头学科之一,在对生命现象与规律的研究中发挥着举足轻重的作用。结构生物学研究手段主要有X......
Huannao Yicong Formula(还脑益聪方) Regulates γ-Secretase Activity through APH-1 and PEN-2 Gene Ragulation
Objective:To observe the effects of Huannao Yicong Formula(还脑益聪方, HYF) on learning and memory and it\'s regulatin......
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ productio
Accumulation of β-amyloid(Aβ)peptide is critical for the pathogenesis of Alzheimers disease....
Background: Berberine(BBR)has neuroprotective effects on a variety of brain diseases,including Alzheimers disease(AD).Th......
γ-secretase inhibitor DAPT prevents neuronal death and memory impairment in sepsis associated enceph
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Amyloid-beta (Aβ) plays a pivotal role in the pathogenesis of Alzheimer\'s disease (AD) and has been regarded as the ......
Effects of chronic cerebral hypoperfusion of beta- and gamma-secretase on learning and memory in rat
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Objective:Presenilin(PS)is one of major causative genes of early onset familial Alzheimers disease(FAD),which accounts f......
目的 探讨γ-分泌酶在铝引起脑内β-淀粉样蛋白(Aβ)蓄积中的作用.方法 32只SD大鼠随机分为对照组,麦芽酚铝低、中、高剂量组(0.4......
目的：研究硒、锌干预对体外淀粉样前体蛋白（amyloid precursor protein，APP）酶解通路的影响。方法用0.1μmol/L的硒、锌处理胚鼠皮层神......
β淀粉样蛋白(Aβ)聚集是阿尔茨海默病(AD)的重要病理特征之一，γ分泌酶对Aβ形成起关键作用，但γ分泌酶存在多种底物蛋白，目前多种在......
Amyloid precursor-like protein 2 C-terminal fragments upregulateS100A9 gene and protein expression i
The murine microglial cell line BV2 has neuroprotective effects, but is toxic to neurons by secret-ing inlfammatory cyto......
Desmoid-type fibromatosis (DF) is a rare monoclonal fibroblastic proliferation that is characterized by locally infiltra......
γ-secretase inhibitor DAPT prevents neuronal death and memory impairment in sepsis associated enceph
Background Brain dysfunction is a frequent complication of sepsis,usually defined as sepsis-associated encephalopathy (S......
Background:Angiotensin Ⅱ (Ang Ⅱ) is a major contributor to the development of heart failure.However,the molecular and ......
Effects of chronic cerebral hypoperfusion of beta- and gamma-secretase on learning and memory in rat
BACKGROUND: Chronic cerebral hypoxia and ischemia have been shown to be related to occurrence of sporadic Alzheimer's di......
Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular
AIM: To confirm the anti-invasion and anti-migration effects of down-regulation of Notch1 combined with interleukin(IL)-......
γ-分泌酶复合体是一种大分子量膜整合蛋白酶复合体,包括早老素、单过性跨膜蛋白、前咽缺陷蛋白1和早老素增强子2四个亚基。γ-分......
目的探讨缺氧条件下乳腺癌细胞γ-分泌酶对Notch信号通路的影响。方法研究该院于2015年4月—2016年4月期间收治的MCF-7乳腺癌患者,......
[摘要]目的采用RNA干扰技术抑制神经母细胞瘤细胞（SH—SY5Y细胞）中α7神经型尼古丁乙酰胆碱受体（nAChR）基因表达，了解对β淀粉样前体蛋......
目的研究Notch信号通路阻断对SH-SY5Y细胞α3神经型尼古丁受体(nAChR)水平的影响。方法用Notch信号通路阻断剂DAPT阻断细胞Notch信......
目的研究早老素-1（PS1）在细胞内pH值降低时的表达情况,探讨细胞内pH值变化对γ-分泌酶活性的影响。方法本研究抑制细胞表面酸碱调节......
对γ-分泌酶抑制剂（LY411575）的合成路线进行改进,新合成路线下该化合物的总收率为35%,比文献方法提高了16%;对关键中间体提前进行了......
γ分泌酶可引起多种膜蛋白的跨膜剪切作用，尤其可导致淀粉样前体蛋白（APP）的跨膜剪切，产生淀粉样蛋白（Aβ）。Aβ易发生沉积而诱发阿尔茨......
Presenilin 1 and presenilin 2 are widely expressed during brain development. Several mutations in these proteins have be......
γ-Secretase is involved in the final processing of the amyloid precursor protein into a heterogeneous pool of β-amyloi......
第一部分TSC患者的突变筛查结节性硬化症(tuberous sclerosis complex,TSC),是一种累及多个系统的常染色体显性遗传的神经皮肤综合......
白血病抑制因子（LIF）是一种多效性细胞因子,作用于多种组织细胞发挥不同的生物学作用,广泛调节细胞的生长、增殖和分化。如LIF抑制胚......
